Ancient Dispersal of the Human Fungal Pathogen Cryptococcus Gattii From the Amazon Rainforest

PLoS One. 2013 Aug 7;8(8):e71148. doi: 10.1371/journal.pone.0071148. Print 2013.

Abstract

Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brazil
  • British Columbia / epidemiology
  • Cells, Cultured
  • Cryptococcosis / epidemiology
  • Cryptococcosis / microbiology*
  • Cryptococcus gattii / classification
  • Cryptococcus gattii / genetics*
  • Cryptococcus gattii / pathogenicity
  • Disease Outbreaks
  • Genes, Fungal
  • Humans
  • Likelihood Functions
  • Macrophages / microbiology
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Multilocus Sequence Typing
  • Mycological Typing Techniques
  • Northwestern United States / epidemiology
  • Phylogeny
  • Polymorphism, Restriction Fragment Length
  • Trees
  • Tropical Climate
  • Virulence

Associated data

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Grant support

This publication was made possible by NPRP grant 5-298-3-06 from the Qatar National Research Fund (a member of Qatar foundation) to TB, JFM, CHWK, and TG. Computational experiments were sponsored by the NCF (Netherlands Computer Facility Foundation) for the use of supercomputer facilities, with financial support from NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek). Contributions of FH were supported by the Odo van Vloten Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.