Low dose of amino-modified nanoparticles induces cell cycle arrest

ACS Nano. 2013 Sep 24;7(9):7483-94. doi: 10.1021/nn403126e. Epub 2013 Aug 19.


The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle Checkpoints / drug effects*
  • Cell Cycle Checkpoints / physiology
  • Cell Line
  • Dose-Response Relationship, Drug
  • Humans
  • Nanoparticles / chemistry
  • Nanoparticles / toxicity*
  • Nitrogen / chemistry*
  • Nitrogen / toxicity*
  • Polystyrenes / chemistry*
  • Polystyrenes / toxicity*
  • Respiratory Mucosa / cytology*
  • Respiratory Mucosa / drug effects*
  • Respiratory Mucosa / physiology


  • Polystyrenes
  • Nitrogen