The comparison of 24-hour urinary sodium, albumin, and protein excretion in chronic kidney disease patients with type 2 diabetes mellitus using insulin detemir or insulin glargine

Clin Drug Investig. 2013 Oct;33(10):773-8. doi: 10.1007/s40261-013-0118-5.

Abstract

Background and objective: Insulin detemir induces bodyweight loss or less weight gain in patients with type 2 diabetes mellitus. However, in contrast to insulin detemir, insulin glargine has no weight loss effect. Increased sodium excretion has been speculated to be one of the mechanisms of weight loss by insulin detemir. However, there are no studies in the literature comparing sodium excretion between patients using insulin detemir and those using insulin glargine. There are also no studies comparing the excretion of urinary albumin and urinary protein in chronic kidney disease (CKD) patients using insulin detemir or insulin glargine. Thus, the aim of the current study was to compare the effects of insulin detemir and insulin glargine on sodium, albumin, and protein excretion in patients with various stages of CKD and concomitant type 2 diabetes.

Methods: Demographic, clinical, and laboratory data were evaluated for all patients. Hypoglycemic attacks, appetite score, 24-h urinary sodium, albumin, and protein excretion were also measured.

Results: A total of 47 patients (23 taking insulin detemir, 24 taking insulin glargine) were included in the study. There were no differences with respect to 24-h sodium (p = 0.694), albumin (p = 0.297), or protein excretion (p = 0.202) between patient groups. Appetite and hypoglycemic attacks also did not differ between groups. Use of insulin detemir or insulin glargine was not related to sodium, albumin, and protein excretion in stepwise regression analysis.

Conclusion: There was no difference between insulin detemir and insulin glargine with respect to sodium, albumin, and protein excretion in type 2 diabetic CKD patients. Studies are needed both in CKD patients and those with normal renal function to highlight mechanisms regarding the weight loss effect unique to insulin detemir.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Aged
  • Albuminuria / drug therapy
  • Albuminuria / urine*
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / urine*
  • Female
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin Detemir
  • Insulin Glargine
  • Insulin, Long-Acting / therapeutic use*
  • Male
  • Middle Aged
  • Proteinuria / drug therapy
  • Proteinuria / urine*
  • Renal Insufficiency, Chronic / drug therapy
  • Renal Insufficiency, Chronic / urine*
  • Sodium / urine*

Substances

  • Hypoglycemic Agents
  • Insulin, Long-Acting
  • Insulin Glargine
  • Insulin Detemir
  • Sodium