Endoscopic retrogade cholangiopancreatography (ERCP) is a standard of care endoscopic technique using a conventional side-viewing duodenoscope to treat a wide variety of biliopancreatic pathologies. However, surgically altered gastric and/or small bowel anatomy renders ERCP more challenging because of several reasons. Depending on the type of surgical reconstruction, different endoscopic approaches have been developed in order to perform therapeutic ERCP. The current review highlights the latest ERCP developments to deal with biliopancreatic problems in patients with surgically altered anatomy, and discusses future directions of improvement.