Fabrication of red-blood-cell-like polyelectrolyte microcapsules and their deformation and recovery behavior through a microcapillary

Adv Mater. 2013 Oct 25;25(40):5814-8. doi: 10.1002/adma.201302875. Epub 2013 Aug 14.


Multilayer microcapsules with a biconcave discoidal shape mimicking red blood cells (RBCs) are fabricated. The structure of the RBC-like microcapsules is verified by scanning electron and confocal laser scanning microscopies. The capsules show elastic deformation after being forced through a microcapillary with a smaller diameter, exhibiting a high recovery ratio of ≈90%. When the capsules are coated with hemoglobin (Hb),they are able to reversibly bind and release oxygen.

Keywords: biomedical applications; biomimetics; layer-by-layer (LbL); microcapsules; oxygen delivery; red blood cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Calcium Hydroxide / chemistry
  • Capsules / chemistry*
  • Electrolytes / chemistry*
  • Erythrocytes / chemistry
  • Erythrocytes / metabolism
  • Hemoglobins / chemistry
  • Hemoglobins / metabolism
  • Oxygen / chemistry
  • Oxygen / metabolism


  • Biocompatible Materials
  • Capsules
  • Electrolytes
  • Hemoglobins
  • Calcium Hydroxide
  • Oxygen