Nutritional status and body composition are already affected before oncology treatment in ovarian cancer

Asia Pac J Clin Nutr. 2013;22(3):426-30. doi: 10.6133/apjcn.2013.22.3.12.

Abstract

Poor nutritional status is a common problem among ovarian cancer patients. In order to detect changes in nutritional status and body composition this study investigates anthropometrical and biochemical parameters among these patients. This study included women with ovarian cancer and woman without cancer. Body composition was assessed by bioelectrical impedance analysis (BIA), anthropometrically, and with DXA scan, and total serum protein, albumin, transferrin, hemoglobin, hematocrit levels and total lymphocyte count was also measured. Data from DXA scan and body composition as assessed by BIA was collected from thirty-one women. Student t-test was used to compare differences in means between groups. This study included 120 women, 57 with ovarian cancer and 63 with benign tumors. Both groups of women were overweight. Body fat by skin-fold thickness, arm circumference, serum albumin, total lymphocytes count, as well as transferrin levels were significantly lower in the ovarian cancer group (p<0.05). Ovarian cancer women had lower fat reserves by skin-fold thickness and lower serum proteins even though they were overweight. However, further studies need to use a body composition assessment on all subjects to confirm these results.

卵巢癌患者營養狀態不佳是常見的問題。本研究以體位及生化參數,評估患 者營養狀態及體組成的變化。研究對象為120 位女性,其中57 位患有卵巢 癌,63 位為良性卵巢瘤,本研究依此將其分為兩組比較。體組成的測量,包 括體脂肪(生物電阻抗法)、體位測量、雙能量骨密度檢測。血液生化值,則包 含總血清蛋白、白蛋白、運鐵蛋白、血紅素、血球容積比,以及總淋巴球計 數。僅31 位女性具有雙能量骨密度檢測及體脂肪資料。獨立t 檢定用於比較 兩組的平均值差異。兩組別婦女皆過重。卵巢癌患者的皮下脂肪厚度、臂 圍、血清白蛋白、總淋巴球計數,以及運鐵蛋白濃度皆顯著較低(p<0.05)。卵 巢癌女性雖過重,但其皮下脂肪儲量以及血清蛋白偏低。然而,此結果仍需 要所有參與者的體組成評估做進一步的確認。

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Anthropometry
  • Blood Proteins / analysis
  • Body Composition / physiology*
  • Electric Impedance
  • Female
  • Hematocrit
  • Hemoglobins / analysis
  • Humans
  • Lymphocyte Count
  • Middle Aged
  • Nutritional Status / physiology*
  • Ovarian Neoplasms / physiopathology*
  • Serum Albumin / analysis
  • Skinfold Thickness
  • Transferrin / analysis

Substances

  • Blood Proteins
  • Hemoglobins
  • Serum Albumin
  • Transferrin