Cutaneous phaeohyphomycosis caused by a rare fungal pathogen, Hormonema dematioides: successful treatment with ketoconazole

J Am Acad Dermatol. 1990 Aug;23(2 Pt 2):363-7. doi: 10.1016/0190-9622(90)70223-5.

Abstract

Annular, fungating, ulcerated lesions developed on both hands of a 64-year-old immunocompetent man 2 months after he was cut with barbed wire. A dematiaceous mold, Hormonema dematioides, heretofore not definitively associated with human disease, was grown from two separate tissue specimens during a period of 9 days. Histopathologic examination demonstrated rare small, periodic acid-Schiff-positive, hyaline, yeastlike organisms in tissue. Twelve weeks of empiric therapy with ketoconazole, 400 mg/day, was curative.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dermatomycoses / drug therapy
  • Dermatomycoses / microbiology*
  • Dermatomycoses / pathology
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / microbiology*
  • Hand Dermatoses / pathology
  • Humans
  • Immune Tolerance
  • Ketoconazole / administration & dosage
  • Ketoconazole / therapeutic use*
  • Male
  • Middle Aged
  • Mitosporic Fungi / isolation & purification
  • Pigmentation Disorders / drug therapy
  • Pigmentation Disorders / microbiology
  • Pigmentation Disorders / pathology

Substances

  • Ketoconazole