Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease

Dement Geriatr Cogn Disord. 2013;36(3-4):242-50. doi: 10.1159/000351671. Epub 2013 Aug 15.


Background/aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia.

Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study.

Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity.

Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / psychology*
  • Attention / physiology
  • Cognition / physiology*
  • Data Interpretation, Statistical
  • Female
  • Frontotemporal Dementia / diagnosis*
  • Frontotemporal Dementia / psychology*
  • Humans
  • Language
  • Male
  • Memory / physiology
  • Middle Aged
  • Neuropsychological Tests*
  • Reproducibility of Results
  • Space Perception / physiology
  • Verbal Learning
  • Visual Perception / physiology
  • Wechsler Scales