Chemotherapy-related cognitive dysfunction: current animal studies and future directions

Brain Imaging Behav. 2013 Dec;7(4):453-9. doi: 10.1007/s11682-013-9250-3.


Cognitive impairment is a potential long-term side effect of adjuvant chemotherapy that can have a major impact on the quality of life of cancer survivors. There is a growing number of preclinical studies addressing this issue, thereby extending our knowledge of the mechanisms underlying chemotherapy-induced neurotoxicity. In this review, we will summarize the recent advances and important findings presented in these studies. Emerging challenges, such as the development of neuroprotective strategies, and the role of the blood-brain barrier on cognitive impairment will be described and future directions in this field of investigation will be outlined.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use*
  • Cognition Disorders / chemically induced*
  • Cognition Disorders / diagnosis
  • Cognition Disorders / physiopathology*
  • Disease Models, Animal*
  • Evidence-Based Medicine
  • Forecasting
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / physiopathology


  • Antineoplastic Agents