Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 9, 1077-86

Intermittent Hypoxia From Obstructive Sleep Apnea May Cause Neuronal Impairment and Dysfunction in Central Nervous System: The Potential Roles Played by Microglia

Affiliations

Intermittent Hypoxia From Obstructive Sleep Apnea May Cause Neuronal Impairment and Dysfunction in Central Nervous System: The Potential Roles Played by Microglia

Qingchan Yang et al. Neuropsychiatr Dis Treat.

Abstract

Obstructive sleep apnea (OSA) is a common condition characterized by repetitive episodes of complete (apnea) or partial (hypopnea) obstruction of the upper airway during sleep, resulting in oxygen desaturation and arousal from sleep. Intermittent hypoxia (IH) resulting from OSA may cause structural neuron damage and dysfunction in the central nervous system (CNS). Clinically, it manifests as neurocognitive and behavioral deficits with oxidative stress and inflammatory impairment as its pathophysiological basis, which are mediated by microglia at the cellular level. Microglia are dominant proinflammatory cells in the CNS. They induce CNS oxidative stress and inflammation, mainly through mitochondria, reduced nicotinamide adenine dinucleotide phosphate oxidase, and the release of excitatory toxic neurotransmitters. The balance between neurotoxic versus protective and anti- versus proinflammatory microglial factors might determine the final roles of microglia after IH exposure from OSA. Microglia inflammatory impairments will continue and cascade persistently upon activation, ultimately resulting in clinically significant neuron damage and dysfunction in the CNS. In this review article, we summarize the mechanisms of structural neuron damage in the CNS and its concomitant dysfunction due to IH from OSA, and the potential roles played by microglia in this process.

Keywords: apoptosis; inflammation; intermittent hypoxia; microglia; obstructive sleep apnea.

Figures

Figure 1
Figure 1
The potential mechanisms of microglia-induced structural neuron damage during IH exposure from OSA. Abbreviations: IH, intermittent hypoxia; OSA, obstructive sleep apnea; iNOS, inducible nitric oxide synthase; RNS, reactive nitrogen species; NMDA, N-methyl-D-aspartate; ROS, reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate; NF-κB, nuclear factor kappa B; TNF, tumor necrosis factor; IL, interleukin.

Similar articles

See all similar articles

Cited by 17 PubMed Central articles

See all "Cited by" articles

References

    1. Staats R, Stoll P, Zingler D, Virchow JC, Lommatzsch M. Regulation of brain-derived neurotrophic factor (BDNF) during sleep apnoea treatment. Thorax. 2005;60:688–692. - PMC - PubMed
    1. Saunamäki T, Himanen SL, Polo O, Jehkonen M. Executive dysfunction in patients with obstructive sleep apnea syndrome. Eur Neurol. 2009;62:237–242. - PubMed
    1. Feng J, Chen BY. Prevalence and incidence of hypertension in obstructive sleep apnea patients and the relationship between obstructive sleep apnea and its confounders. Chin Med J (Engl) 2009;122:1464–1468. - PubMed
    1. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165:1217–1239. - PubMed
    1. National Heart, Lung, and Blood Institute Working Group on Sleep Apnea Sleep apnea: is your patient at risk? Am Fam Physician. 1996;53:247–253. - PubMed
Feedback