Presentation of suspected pediatric uveitis

Semin Ophthalmol. 2014 Jan;29(1):4-7. doi: 10.3109/08820538.2013.810288. Epub 2013 Aug 16.

Abstract

Presentation of suspected pediatric uveitis: Pediatric uveitis is usually managed in specialized ophthalmic centers in the UK. Meaningful data acquisition in these clinics may be helpful in clinical governance, and healthcare planning in a specialty that is gradually changing due to changes in treatment choices.

Methods: Retrospective analysis of prospectively acquired data in the Liverpool pediatric uveitis database was performed.

Results: Analysis of our data, based on 147 patients, with a mean age of 10 years, indicated a female to male ratio of 2:1. 99% of patients were Caucasian. Our data indicates 86% of all patients attending the uveitis clinic were diagnosed with juvenile idiopathic arthritis, followed by intermediate uveitis 5% and idiopathic uveitis 4%. 46% of patients required treatment. Systemic treatment included methotrexate (34%), prednisolone (14%), etanercept (6%), ciclosporin (6%), mycophenolate (3%), and infliximab (1%). Severe visual loss (defined by counting fingers or below vision) was seen in 10 eyes despite appropriately treated chronic uveitis.

Conclusion: Our data shows uveitis-related ocular morbidity in a predominantly pediatric Caucasian population. Patients with severe and chronic uveitis may experience significant uveitis-related complications and subsequent visual loss despite aggressive treatment.

MeSH terms

  • Adolescent
  • Antibodies, Antinuclear / blood
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Juvenile / diagnosis*
  • Arthritis, Juvenile / drug therapy
  • Child
  • Child, Preschool
  • Female
  • HLA-B27 Antigen / analysis
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Uveitis / diagnosis*
  • Uveitis / drug therapy
  • Vision Disorders / diagnosis
  • Visual Acuity
  • Young Adult

Substances

  • Antibodies, Antinuclear
  • Antirheumatic Agents
  • HLA-B27 Antigen