In vitro evaluation of a novel topical cream for vitiligo and psoriasis that selectively delivers NB-UVB therapy when exposed to sunlight

Dermatol Ther. Mar-Apr 2014;27(2):117-20. doi: 10.1111/dth.12079. Epub 2013 Jul 16.

Abstract

Ultraviolet-B (UVB) phototherapy is a well-established mode of treatment for several types of dermatological disease. For psoriasis and vitiligo, narrow band UVB (NB-UVB) phototherapy is an effective therapy, demonstrating greater efficacy and safety compared to broadband UVB or psoralen plus UVA treatments. While the treatment efficacy of NB-UVB artificial light sources is well documented, the long term time and cost commitment of the therapy remains a barrier to treatment adherence. Natural sunlight is an ideal source of accessible UVB radiation; however, exposure to natural sunlight generally results in erythema prior to the accumulation of sufficient dosage of therapeutic wavelengths of UVB. This communication describes a novel topical cream designed to selectively deliver NB-UVB therapy when exposed to sunlight. The topical cream when combined with natural sunlight could offer patients a more convenient phototherapy option for psoriasis and vitiligo, potentially increasing patient compliance.

Keywords: phototherapy; psoriasis; vitiligo.

MeSH terms

  • Administration, Cutaneous
  • Humans
  • Photosensitizing Agents / administration & dosage
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / radiation effects*
  • Psoriasis / therapy*
  • Spectrophotometry, Ultraviolet
  • Sunlight*
  • Ultraviolet Therapy / methods*
  • Vitiligo / diagnosis
  • Vitiligo / therapy*

Substances

  • Photosensitizing Agents