Single-molecule approaches embrace molecular cohorts

Cell. 2013 Aug 15;154(4):723-6. doi: 10.1016/j.cell.2013.07.012.


Enormous mechanistic insight has been gained by studying the behavior of single molecules. The same approaches used to study proteins in isolation are now being leveraged to examine the changes in functional behavior that emerge when single molecules have company.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacteria / metabolism
  • Biochemical Phenomena
  • DNA / chemistry
  • DNA / metabolism*
  • Gene Expression Regulation
  • Molecular Biology / methods*
  • Protein Folding
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism*
  • Transcription, Genetic


  • Transcription Factors
  • DNA