Oxidative stress and immune thrombocytopenia

Semin Hematol. 2013 Jul;50(3):e1-4. doi: 10.1053/j.seminhematol.2013.06.011.


Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased platelet destruction or decreased platelet production. The mechanism of the disease has been extensively studied so that we now have a much improved understanding of the pathophysiology; however, the trigger of the autoimmunity remains unclear. More recently, oxidative stress was identified to be involved in the pathogenesis of ITP and provides a new hypothesis for the initiation of autoimmunity in patients with ITP. In this review, oxidative stress and its impact on autoimmunity, particularly ITP, will be covered.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoimmunity
  • Humans
  • Oxidative Stress*
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / metabolism
  • Thrombocytopenia / immunology*
  • Thrombocytopenia / metabolism
  • Thrombocytopenia / pathology


  • Reactive Nitrogen Species
  • Reactive Oxygen Species