Postoperative enteral nutrition improves survival after orthotopic small bowel transplantation in mice

Transplant Proc. 2013 Jul-Aug;45(6):2543-5. doi: 10.1016/j.transproceed.2013.02.121.

Abstract

Background: The aim of this study was to assess the effect postoperative enteral nutrition support on the survival after orthotopic small bowel transplantation in mice.

Methods: A model of orthotopic small bowel transplantation used C57BL/6 mice as both donors and recipients.

Results: We demonstrated that postoperative ileus was the deciding complication after transplantation. Postoperative enteral nutritional support resolved this problem and significantly improved survival and growth rates after transplantation.

Conclusion: These data suggest the importance of routine nutritional support after orthotopic small bowel transplantation in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Nutritional Physiological Phenomena
  • Animals
  • Enteral Nutrition*
  • Female
  • Ileus / etiology
  • Ileus / pathology
  • Ileus / physiopathology
  • Ileus / prevention & control*
  • Intestine, Small / pathology
  • Intestine, Small / transplantation*
  • Mice
  • Mice, Inbred C57BL
  • Models, Animal
  • Nutritional Status
  • Organ Size
  • Organ Transplantation
  • Postoperative Care
  • Time Factors