Modeling myocardial growth and hypertrophy in engineered heart muscle

Trends Cardiovasc Med. 2014 Jan;24(1):7-13. doi: 10.1016/j.tcm.2013.05.003. Epub 2013 Aug 15.


The introduction of biomimetic culture paradigms has advanced myocardial tissue engineering fundamentally, enabling today the provision of engineered rodent and human heart muscle with features characteristically found in postnatal myocardium. This is in marked contrasts to "flat" cardiomyocyte cultures with their typically low degree of organotypic maturation. Here, we discuss the collagen hydrogel-based engineered heart muscle (EHM) technology and provide background information on its use in simulations of myocardial growth and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomimetics
  • Cardiomegaly / metabolism
  • Cardiomegaly / pathology*
  • Cell Culture Techniques
  • Cell Proliferation*
  • Cell Shape
  • Collagen / metabolism
  • Humans
  • Hydrogels
  • Myocardium / metabolism
  • Myocardium / pathology*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / pathology*
  • Tissue Engineering / methods*


  • Hydrogels
  • Collagen