Effects of acute physical exercise on aryl hydrocarbon hydroxylase activity in human peripheral lymphocytes

Life Sci. 1990;47(5):427-32. doi: 10.1016/0024-3205(90)90301-7.


It has been reported that physical exercise may enhance cytochrome P-450 dependent drug metabolism in vivo. In this study we report that the specific activity of aryl hydrocarbon hydroxylase (AHH) in human peripheral lymphocytes (HPL) is enhanced approximately two fold following acute physical exercise. This enhancement of AHH activity in HPL appears to be strongly correlated with enhanced lymphocyte count as well as induced metabolic and exercise stress but not with the intrinsic physical fitness of individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aryl Hydrocarbon Hydroxylases / biosynthesis*
  • Exercise / physiology*
  • Female
  • Heart Rate
  • Humans
  • Leukocyte Count
  • Lymphocytes / enzymology*
  • Male
  • Pulmonary Gas Exchange


  • Aryl Hydrocarbon Hydroxylases