Bacterial persistence: finding the "sweet spot"

Cell Host Microbe. 2013 Aug 14;14(2):119-20. doi: 10.1016/j.chom.2013.07.016.

Abstract

Studies described by Eisele et al. (2013) and Xavier et al. (2013) in this issue of Cell Host & Microbe show that the bacterial pathogens Salmonella and Brucella exploit the increased levels of glucose present in alternatively activated macrophages to sustain chronic infections in experimentally infected mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brucella abortus / physiology*
  • Glucose / metabolism*
  • Host-Pathogen Interactions*
  • Macrophage Activation*
  • Macrophages / microbiology*
  • Microbial Viability*
  • PPAR delta / metabolism*
  • PPAR gamma / metabolism*
  • Salmonella typhimurium / physiology*

Substances

  • PPAR delta
  • PPAR gamma
  • Glucose