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Randomized Controlled Trial
. 2013 Nov;156(5):1045-50.
doi: 10.1016/j.ajo.2013.06.014. Epub 2013 Aug 15.

A Comparison of Treatment Approaches for Bilateral Congenital Nasolacrimal Duct Obstruction

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Free PMC article
Randomized Controlled Trial

A Comparison of Treatment Approaches for Bilateral Congenital Nasolacrimal Duct Obstruction

Katherine A Lee et al. Am J Ophthalmol. .
Free PMC article

Abstract

Purpose: To compare the clinical outcomes of two treatment approaches for bilateral nasolacrimal duct obstruction (NLDO) in infancy.

Design: Multicenter, randomized clinical trial.

Methods: We studied 57 infants between the ages of 6 and <10 months who had bilateral NLDO. Participants were randomized to receive either (1) immediate office-based probing within two weeks (n = 31) or (2) 6 months of observation and nonsurgical management followed by surgical facility-based probing for unresolved cases (n = 26). Treatment success was defined as the absence of clinical signs of NLDO (epiphora, increased tear lake, mucous discharge) in both eyes on masked examination at 18 months of age.

Results: In the observation and deferred facility probing group, resolution without surgery occurred by 6 months after randomization in both eyes for 14 participants (56%), in one eye for 5 (20%), and in neither eye for 6 (24%). Eight participants in the observation and deferred facility probing group underwent facility probing (one of whom later had a second facility probing). Four participants in the immediate office probing group later underwent an additional procedure in a surgical facility. In the immediate office probing group, treatment success at 18 months of age occurred in both eyes for 19 of 29 (66%) participants and in one eye for 3 (10%); in the observation and deferred facility probing group, treatment success occurred in both eyes for 19 of 25 (76%) participants and in one eye for 3 (12%) (difference in success = -10%; 95% CI = -35% to 14%).

Conclusions: Both the immediate office probing approach and the observation and deferred facility probing approach are successful and reasonable treatment options for infants with bilateral NLDO.

Figures

Figure 1
Figure 1. Flow Chart of Patients with Bilateral Congenital Nasolacrimal Duct Obstruction
*Of the 6 immediate office group patients who withdrew from the study before the primary outcome visit at 18 months of age, the parents were able to be contacted by phone in 4 cases and therefore these 4 patients were included in the analysis.

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