Fibrosis and adipose tissue dysfunction

Cell Metab. 2013 Oct 1;18(4):470-7. doi: 10.1016/j.cmet.2013.06.016. Epub 2013 Aug 15.


Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an equally important role on systemic metabolic alterations as fibrotic conditions play in the liver, heart, and kidney. Here, we discuss recent advances in our understanding of the genesis, modulation, and systemic impact of excessive extracellular matrix (ECM) accumulation in adipose tissue of both rodents and humans and the ensuing impact on metabolic dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / metabolism*
  • Cytokines / metabolism
  • Fibrosis / metabolism*
  • Fibrosis / pathology
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Insulin Resistance
  • Obesity / metabolism
  • Obesity / pathology


  • Cytokines
  • Hypoxia-Inducible Factor 1, alpha Subunit