ACE2 alterations in kidney disease

Nephrol Dial Transplant. 2013 Nov;28(11):2687-97. doi: 10.1093/ndt/gft320. Epub 2013 Aug 16.


Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(1-7). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney disease, hypertensive renal disease and in different models of kidney injury. There is often a dissociation between tubular and glomerular ACE2 expression, particularly in diabetic kidney disease where ACE2 expression is increased at the tubular level but decreased at the glomerular level. In this review, we will discuss alterations in circulating and renal ACE2 recently described in different renal pathologies and disease models as well as their possible significance.

Keywords: ACE2; kidney disease; renin–angiotensin system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Humans
  • Kidney Diseases / enzymology*
  • Kidney Diseases / pathology
  • Kidney Glomerulus / enzymology
  • Kidney Tubules / enzymology
  • Peptidyl-Dipeptidase A / metabolism*
  • Renin-Angiotensin System / physiology


  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2