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, 16 (4), 342-6

Role of Casein Phosphopeptide Amorphous Calcium Phosphate in Remineralization of White Spot Lesions and Inhibition of Streptococcus Mutans?


Role of Casein Phosphopeptide Amorphous Calcium Phosphate in Remineralization of White Spot Lesions and Inhibition of Streptococcus Mutans?

Ruchi Vashisht et al. J Conserv Dent.

Retraction in


Introduction: To promote the remineralization by ionic exchange mechanism instead of invasive techniques many remineralizing agents can be used.

Objective: To evaluate the remineralization effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on white spot lesions (WSLs) and its inhibitory effect on Streptococcus mutans colonization.

Materials and methods: The study group consisted of 60 subjects exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: A test group using CPP-ACP cream (GC-Tooth Mousse, Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-month. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva collection was repeated.

Result: DIAGNOdent measurements were increased by time (P = 0.002) in the control group and no statistically significant difference (P = 0.217) was found in the test group by the 3-month period. In both groups, the mutans counts were decreased in the 3-month experimental period.

Conclusion: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however, longer observation is recommended to confirm whether the greater change in WSLs is maintained.

Keywords: Casein phosphopeptide-amorphous calcium phosphate; enamel; remineralization; white-spotlesions.

Conflict of interest statement

Conflict of Interest: None declared


Figure 1
Figure 1
DIAGNOdent measurements, (*) presents statistically significant difference
Figure 2
Figure 2
Intraoral photographs of a patient (a) white spot lesions were seen at baseline; (b and c) at 3-month evaluation period after the application of tooth mousse
Figure 3
Figure 3
Intraoral photographs of a patient (a) at baseline; (b) after the 3-month evaluation period after using tooth mousse 161 mm × 164 mm
Figure 4
Figure 4
Streptococcus mutans levels in the saliva at the baseline and 3-month periods, (*, ^) presents statistically significant

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