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, 16 (4), 342-6

Role of Casein Phosphopeptide Amorphous Calcium Phosphate in Remineralization of White Spot Lesions and Inhibition of Streptococcus Mutans?

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Role of Casein Phosphopeptide Amorphous Calcium Phosphate in Remineralization of White Spot Lesions and Inhibition of Streptococcus Mutans?

Ruchi Vashisht et al. J Conserv Dent.

Retraction in

Abstract

Introduction: To promote the remineralization by ionic exchange mechanism instead of invasive techniques many remineralizing agents can be used.

Objective: To evaluate the remineralization effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on white spot lesions (WSLs) and its inhibitory effect on Streptococcus mutans colonization.

Materials and methods: The study group consisted of 60 subjects exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: A test group using CPP-ACP cream (GC-Tooth Mousse, Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-month. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva collection was repeated.

Result: DIAGNOdent measurements were increased by time (P = 0.002) in the control group and no statistically significant difference (P = 0.217) was found in the test group by the 3-month period. In both groups, the mutans counts were decreased in the 3-month experimental period.

Conclusion: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however, longer observation is recommended to confirm whether the greater change in WSLs is maintained.

Keywords: Casein phosphopeptide-amorphous calcium phosphate; enamel; remineralization; white-spotlesions.

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
DIAGNOdent measurements, (*) presents statistically significant difference
Figure 2
Figure 2
Intraoral photographs of a patient (a) white spot lesions were seen at baseline; (b and c) at 3-month evaluation period after the application of tooth mousse
Figure 3
Figure 3
Intraoral photographs of a patient (a) at baseline; (b) after the 3-month evaluation period after using tooth mousse 161 mm × 164 mm
Figure 4
Figure 4
Streptococcus mutans levels in the saliva at the baseline and 3-month periods, (*, ^) presents statistically significant

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