[The Anti-Inflammatory Effect of Fullerene C60 on Adjuvant Arthritis in Rats]

Fiziol Zh. 2013;59(3):102-10.
[Article in Ukrainian]

Abstract

The anti-inflammatory properties of non-modified fullerene C60 (FC60) by adjuvant arthritis in Wistar rats have been studied. It was shown that the intraperitoneal introduction of FC60 (50 ng) reveals an anti-inflammatory and chondroprotective actions in the phase of systemic manifestation of adjuvant arthritis. The effect was carried out by limitation of inflammation of damaged limb, normalization of body weight, the decrease in body temperature. Introduction of FC60 promote the reduction of leukocyte level, the erythrocyte sedimentation rate, concentrations of sialic acids and the ceruloplasmin levels, processes degeneration of cartilaginous tissues of the joint of rats. It has been concluded that the therapeutic effectiveness of non-modified FC60 in experimental adjuvant arthritis is comparable with the action of water-soluble forms of fullerenes. The results substantiate the future investigations of non-modified FC60 for design of therapeutic agents for treatment of rheumatoid arthritis in clinics.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Arthritis, Experimental / drug therapy*
  • Arthritis, Experimental / immunology
  • Arthritis, Experimental / pathology
  • Blood Sedimentation / drug effects
  • Body Temperature / drug effects
  • Body Weight / drug effects
  • Cartilage / drug effects*
  • Cartilage / immunology
  • Cartilage / pathology
  • Ceruloplasmin / antagonists & inhibitors
  • Fullerenes / pharmacology*
  • Inflammation / prevention & control
  • Injections, Intraperitoneal
  • Knee Joint / drug effects*
  • Knee Joint / immunology
  • Knee Joint / pathology
  • Leukocytes / drug effects
  • Leukocytes / immunology
  • Leukocytes / pathology
  • Male
  • Rats
  • Rats, Wistar

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Fullerenes
  • Ceruloplasmin
  • fullerene C60