Trisequential photooxygenation reaction: application to the synthesis of carbasugars

Org Lett. 2013 Sep 6;15(17):4350-3. doi: 10.1021/ol401823m. Epub 2013 Aug 20.

Abstract

4,5-Dimethylenecyclohex-1-ene was subjected to a photooxygenation reaction to introduce oxygen functionalities. The endoperoxide obtained underwent an ene-reaction to form hydroperoxides with 1,3-diene structures. Further addition of singlet oxygen to the diene units resulted in the formation of tricyclic hydroperoxides having three oxygens in the molecule. Cleavage of the oxygen-oxygen bonds followed by epoxidation of the remaining C-C double bond and concomitant ring-opening reaction furnished the isomeric carbasugars.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbasugars / chemical synthesis*
  • Carbasugars / chemistry
  • Cyclohexenes / chemistry*
  • Hydrogen Peroxide / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Singlet Oxygen / chemistry
  • Stereoisomerism

Substances

  • 4,5-dimethylenecyclohex-1-ene
  • Carbasugars
  • Cyclohexenes
  • Singlet Oxygen
  • Hydrogen Peroxide