Platelets in tissue repair: control of apoptosis and interactions with regenerative cells

Blood. 2013 Oct 10;122(15):2550-4. doi: 10.1182/blood-2013-05-468694. Epub 2013 Aug 20.


Besides mediating primary hemostasis and thrombosis, platelets play a critical role in tissue repair and regeneration. They regulate fundamental mechanisms involved in the healing process including cellular migration, proliferation, and angiogenesis. Control of apoptosis/cell survival and interaction with progenitor cells, which are clinically relevant but poorly understood aspects of platelets in tissue repair, will be highlighted in this review. Gaining deeper insight into the less well-characterized molecular mechanisms is necessary to develop new therapeutic platelet-based options.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Blood Platelets / physiology*
  • Guided Tissue Regeneration*
  • Humans
  • Regeneration / physiology*
  • Wound Healing / physiology*