Role of endogenous cannabinoid system in the gut

Sheng Li Xue Bao. 2013 Aug 25;65(4):451-60.


The plant Cannabis has been used in clinic for centuries, and has been known to be beneficial in a variety of gastrointestinal diseases, such as emesis, diarrhea, inflammatory bowel disease and intestinal pain. In this text, we'll review the components of the endogenous cannabinoid system as well as its role in the regulation of gastrointestinal activities, thus providing relative information for further study. Moreover, modulation of the endogenous cannabinoid system in gastrointestinal tract may provide a useful therapeutic target for gastrointestinal disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cannabinoid Receptor Modulators / pharmacology*
  • Endocannabinoids / physiology*
  • Gastrointestinal Diseases / physiopathology
  • Gastrointestinal Tract / physiology*
  • Humans


  • Cannabinoid Receptor Modulators
  • Endocannabinoids