Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans

J Infect Dis. 2014 Feb 1;209(3):355-9. doi: 10.1093/infdis/jit444. Epub 2013 Aug 20.

Abstract

To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10(-4)), as was one 81-kb haplotype (adjusted P = .0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.

Keywords: Tim 1; hepatitis C virus; human genetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • African Americans
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Hepatitis A Virus Cellular Receptor 1
  • Hepatitis C, Chronic / genetics*
  • Humans
  • Male
  • Membrane Glycoproteins / genetics*
  • Polymorphism, Genetic
  • Receptors, Virus / genetics*

Substances

  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • Membrane Glycoproteins
  • Receptors, Virus