NF90 in posttranscriptional gene regulation and microRNA biogenesis

Int J Mol Sci. 2013 Aug 19;14(8):17111-21. doi: 10.3390/ijms140817111.


Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / biosynthesis*
  • MicroRNAs / genetics
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Nuclear Factor 90 Proteins / physiology*
  • Protein Biosynthesis
  • RNA Interference*
  • RNA Stability
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism


  • ILF3 protein, human
  • MicroRNAs
  • Nuclear Factor 90 Proteins
  • RNA, Messenger