Tranexamic Acid Accelerates Skin Barrier Recovery and Upregulates Occludin in Damaged Skin

Int J Dermatol. 2014 Aug;53(8):959-65. doi: 10.1111/ijd.12099. Epub 2013 Aug 22.

Abstract

Background: Tranexamic acid (TA) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become the topic of a lot of research. The aim of this study is to determine whether TA could repair the skin barrier by means of tight intercellular junctions.

Methods: Two kinds of damaged skin models were set up and subjected to repeated application of sodium lauryl sulfate and irradiation of ultraviolet B. Through bioengineering technology and immunohistochemistry tests, TA-induced changes in skin were detected.

Results: After 1, 3, 7, and 14 days of application, TA can significantly accelerate barrier recovery and decrease the melanin index values of ultraviolet B irritation skin. The mean optic density of occludin from TA treatment is higher than from self-repair.

Conclusion: These experiments suggest that TA can accelerate skin barrier recovery and upregulate occludin induced by physicochemical damages of human skin, but it is advisable to perform more research on the upregulation of occludin in molecular mechanism in the future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antifibrinolytic Agents / pharmacology*
  • Erythema / drug therapy
  • Erythema / etiology
  • Female
  • Humans
  • Male
  • Melanins / analysis
  • Middle Aged
  • Occludin / analysis
  • Radiation Injuries / drug therapy
  • Radiation Injuries / etiology
  • Skin / chemistry
  • Skin / drug effects*
  • Skin / radiation effects
  • Skin Physiological Phenomena / drug effects*
  • Sodium Dodecyl Sulfate / pharmacology
  • Tight Junctions / drug effects
  • Tranexamic Acid / pharmacology*
  • Ultraviolet Rays / adverse effects
  • Up-Regulation / drug effects
  • Wound Healing / drug effects*
  • Wound Healing / physiology
  • Young Adult

Substances

  • Antifibrinolytic Agents
  • Melanins
  • Occludin
  • Sodium Dodecyl Sulfate
  • Tranexamic Acid