Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial

Psychol Med. 2014 May;44(7):1545-52. doi: 10.1017/S0033291713002201. Epub 2013 Aug 23.


Background: Pain is a common symptom of chronic fatigue syndrome (CFS). We investigated the effects of the treatments used in the PACE trial [cognitive behavioural therapy (CBT), graded exercise therapy (GET), adaptive pacing therapy (APT) and specialist medical care (SMC)] on pain in CFS.

Method: We compared pain outcomes including individual painful symptoms, taken from the CDC criteria for CFS and co-morbid fibromyalgia. We modelled outcomes adjusting for baseline variables with multiple linear regression.

Results: Significantly less frequent muscle pain was reported by patients following treatment with CBT compared to SMC (mean difference = 0.38 unit change in frequency, p = 0.02), GET versus SMC (0.42, p = 0.01) and GET versus APT (0.37, p = 0.01). Significantly less joint pain was reported following CBT versus APT (0.35, p = 0.02) and GET versus APT (0.36, p = 0.02). Co-morbid fibromyalgia was less frequent following GET versus SMC (0.03, p = 0.03). The effect sizes of these differences varied between 0.25 and 0.31 for muscle pain and 0.24 and 0.26 for joint pain. Treatment effects on pain were independent of 'change in fatigue'.

Conclusions: CBT and GET were more effective in reducing the frequency of both muscle and joint pain than APT and SMC. When compared to SMC, GET also reduced the frequency of co-morbid fibromyalgia; the size of this effect on pain was small.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthralgia / rehabilitation
  • Chronic Pain / rehabilitation
  • Cognitive Behavioral Therapy / methods*
  • Combined Modality Therapy / methods
  • Exercise Therapy / methods*
  • Fatigue Syndrome, Chronic / complications
  • Fatigue Syndrome, Chronic / rehabilitation*
  • Female
  • Fibromyalgia / rehabilitation*
  • Humans
  • Male
  • Middle Aged
  • Myalgia / rehabilitation
  • Pain / rehabilitation*
  • Treatment Outcome

Associated data

  • ISRCTN/ISRCTN54285094