Potential role of advanced MRI techniques for the peritumoural region in differentiating glioblastoma multiforme and solitary metastatic lesions

Clin Radiol. 2013 Dec;68(12):e689-97. doi: 10.1016/j.crad.2013.06.021. Epub 2013 Aug 19.


Differentiation between solitary metastatic lesions and glioblastomas, two of the most common malignant brain neoplasms, is often a diagnostic challenge. The purpose of this review is to emphasize the potential roles of advanced magnetic resonance imaging (MRI) techniques, including diffusion-based techniques, such as diffusion-weighted imaging (DWI), exponential DWI, and diffusion tensor imaging, MR perfusion, and MR spectroscopy, as well as conventional MRI, in making a distinction between glioblastomas and solitary metastases in peritumoural regions. Integration of advanced MRI features with conventional MRI, may provide valuable information for differentiating glioblastoma from solitary metastatic lesions.

Publication types

  • Review

MeSH terms

  • Aged
  • Brain / pathology
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Diagnosis, Differential
  • Female
  • Glioblastoma / diagnosis*
  • Glioblastoma / pathology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Neuroimaging / methods*