The circadian clock and cell cycle: interconnected biological circuits

Curr Opin Cell Biol. 2013 Dec;25(6):730-4. doi: 10.1016/ Epub 2013 Aug 19.


The circadian clock governs biological timekeeping on a systemic level, helping to regulate and maintain physiological processes, including endocrine and metabolic pathways with a periodicity of 24-hours. Disruption within the circadian clock machinery has been linked to numerous pathological conditions, including cancer, suggesting that clock-dependent regulation of the cell cycle is an essential control mechanism. This review will highlight recent advances on the 'gating' controls of the circadian clock at various checkpoints of the cell cycle and also how the cell cycle can influence biological rhythms. The reciprocal influence that the circadian clock and cell cycle exert on each other suggests that these intertwined biological circuits are essential and multiple regulatory/control steps have been instated to ensure proper timekeeping.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / metabolism
  • Circadian Clocks / physiology*
  • Circadian Rhythm / physiology
  • Humans
  • Metabolic Networks and Pathways / physiology
  • Neoplasms / metabolism
  • Neoplasms / pathology


  • Cell Cycle Proteins