Medical research: Trial unpredictability yields predictable therapy gains

Nature. 2013 Aug 22;500(7463):395-6. doi: 10.1038/500395a.


In decades of clinical-trial data, new treatments are better than standard ones just over half the time. That's as it should be, say Benjamin Djulbegovic and colleagues.

MeSH terms

  • Biomedical Research / statistics & numerical data*
  • Comparative Effectiveness Research*
  • Drug Discovery / statistics & numerical data*
  • Humans
  • Randomized Controlled Trials as Topic / statistics & numerical data*
  • Therapeutic Equipoise*
  • Treatment Outcome
  • Uncertainty