Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

Nat Rev Immunol. 2013 Sep;13(9):693-701. doi: 10.1038/nri3516.


The field of HIV-1 vaccine research has seen a renaissance with the identification of antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural mode of target recognition that these antibodies use and the immune pathways that lead to their development is emerging. This knowledge has provided fundamental insights into the pathways that elicit broadly neutralizing antibodies and provides a foundation for active and passive immunization strategies to prevent HIV-1 infection.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • AIDS Vaccines / immunology*
  • Antibodies, Neutralizing / immunology*
  • HIV Infections / immunology*
  • HIV Infections / prevention & control*
  • HIV-1 / immunology*
  • Humans


  • AIDS Vaccines
  • Antibodies, Neutralizing