A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface

Lab Chip. 2013 Nov 7;13(21):4160-3. doi: 10.1039/c3lc50571e.

Abstract

From the lungs to the central nervous system, cilia-driven fluid flow plays a fundamental role in many facets of life. Yet, there are few quantitative methods for analysing the function of ciliated surfaces. Here, we report a novel microfluidic approach for quantifying the performance of a ciliated surface using mixing performance as an integrated readout.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cilia / physiology*
  • Embryo, Nonmammalian / physiology
  • Microfluidic Analytical Techniques / instrumentation
  • Microfluidic Analytical Techniques / methods*
  • Surface Properties
  • Xenopus / growth & development