One inositol ring to rule thrombosis

Blood. 2013 Aug 22;122(8):1331-2. doi: 10.1182/blood-2013-07-511006.

Abstract

In this issue of Blood, Ghosh and colleagues report that knocking out an inositol kinase in mice diminishes polyphosphate in platelet dense granules, thereby reducing hemostasis and protecting against thrombosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood Platelets / metabolism*
  • Male
  • Phosphotransferases (Phosphate Group Acceptor) / physiology*
  • Polyphosphates / metabolism*

Substances

  • Polyphosphates
  • Phosphotransferases (Phosphate Group Acceptor)
  • inositol hexakisphosphate kinase