Efficacy of an imidacloprid/flumethrin collar against fleas, ticks and tick-borne pathogens in dogs

Parasit Vectors. 2013 Aug 23;6(1):245. doi: 10.1186/1756-3305-6-245.


Background: Tick-borne diseases comprise a group of maladies that are of substantial medical and veterinary significance. A range of tick-borne pathogens, including diverse species of bacteria and protozoa, can infect both dogs and humans. Hence, the control of tick infestations is pivotal to decrease or prevent tick-borne pathogen transmission. Therefore, different commercial products with insecticidal, repellent or both properties have been developed for use on dogs. Recently, a collar containing a combination of imidacloprid 10% and flumethrin 4.5% has proven effective to prevent tick and flea infestations in dogs under field conditions and the infection by some vector-borne pathogens they transmit under laboratory-controlled conditions.

Methods: From March 2011 to April 2012, a field study was conducted in a private shelter in southern Italy to assess the efficacy of the imidacloprid/flumethrin collar against tick and flea infestations and to determine if this strategy would decrease tick-borne pathogen transmission in young dogs. A total of 122 animals were enrolled in the study and randomly assigned to group A (n = 64; collared) or group B (n = 58; untreated controls). Dogs were examined monthly for ticks and fleas and systematically tested for selected tick-borne pathogens.

Results: Compared to controls, the collar provided overall efficacies of 99.7% and 100% against tick and flea infestation, respectively. The overall efficacy for the prevention of tick-borne pathogens (i.e., Anaplasma platys and Babesia vogeli) was 91.6%.

Conclusions: This study demonstrates that the imidacloprid/flumethrin collar is efficacious against flea and tick infestation as well as tick-borne pathogen transmission to dogs under field conditions.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Animals
  • Dog Diseases / prevention & control*
  • Dogs
  • Female
  • Flea Infestations / prevention & control
  • Flea Infestations / veterinary*
  • Imidazoles / administration & dosage*
  • Insecticides / administration & dosage*
  • Male
  • Neonicotinoids
  • Nitro Compounds / administration & dosage*
  • Pyrethrins / administration & dosage*
  • Tick Infestations / prevention & control
  • Tick Infestations / veterinary*
  • Tick-Borne Diseases / prevention & control
  • Tick-Borne Diseases / veterinary*
  • Treatment Outcome


  • Imidazoles
  • Insecticides
  • Neonicotinoids
  • Nitro Compounds
  • Pyrethrins
  • flumethrin
  • imidacloprid