Reduction of retinal sensitivity in eyes with reticular pseudodrusen

Am J Ophthalmol. 2013 Dec;156(6):1184-1191.e2. doi: 10.1016/j.ajo.2013.06.036. Epub 2013 Aug 20.


Purpose: To evaluate the effect of macular reticular pseudodrusen on retinal function using multiple imaging methods.

Design: Prospective cross-sectional study.

Methods: Thirteen eyes with reticular pseudodrusen, but without any other macular abnormality or glaucoma, and 20 normal eyes were evaluated. All subjects underwent color fundus photography, infrared reflectance (IR), fundus autofluorescence (FAF), and microperimetry.

Results: The similarity in the number of reticular pseudodrusen was evaluated through inter-observer intraclass correlation coefficients, which ranged from 0.852-0.944. IR could detect reticular pseudodrusen within the center circle area in 12 eyes, whereas blue-channel fundus photography and FAF could only detect these lesions in 1 and 3 eyes, respectively. The number of reticular pseudodrusen correlated among the different imaging modalities (P < .001 for all) for all areas of the macula, except the center. The mean retinal sensitivity in eyes with reticular pseudodrusen was lower in all areas of the macula, compared with normal eyes (P < .001 for all). The number of reticular pseudodrusen correlated with retinal sensitivity in all areas by IR imaging (P = .003, P < .001, P = .003 for center, inner ring, outer ring, respectively), in the inner and outer rings by blue-channel fundus photography (P < .001 for both), and in the inner and outer rings by FAF (P < .001 and P = .001, respectively).

Conclusions: Although multiple imaging modalities are capable of quantifying reticular pseudodrusen, IR appears to have the best ability to do so as compared to blue-channel photography and FAF. The distribution and number of reticular pseudodrusen lesions are closely associated with retinal sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Coloring Agents
  • Cross-Sectional Studies
  • Female
  • Fluorescein Angiography
  • Humans
  • Indocyanine Green
  • Male
  • Middle Aged
  • Multimodal Imaging / methods
  • Photography
  • Prospective Studies
  • Retina / physiopathology*
  • Retinal Drusen / diagnosis
  • Retinal Drusen / physiopathology*
  • Vision Disorders / diagnosis
  • Vision Disorders / physiopathology*
  • Visual Acuity / physiology
  • Visual Field Tests


  • Coloring Agents
  • Indocyanine Green