Generating CD8 T cell heterogeneity: attack of the clones

Immunity. 2013 Aug 22;39(2):203-5. doi: 10.1016/j.immuni.2013.08.008.


Pathogen-induced inflammation modulates CD8 T cell effector and memory differentiation. In this issue of Immunity, Plumlee et al. (2013) demonstrate that clonally distinct CD8 T cells have the ability to generate numerous types of effector cell fates based on extrinsic pathogen-induced environmental cues.

Publication types

  • Comment

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Female
  • Listeriosis / immunology*
  • Vesicular Stomatitis / immunology*