Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 5 (1), 226-35

A Historical Overview of Bacteriophage Therapy as an Alternative to Antibiotics for the Treatment of Bacterial Pathogens

Affiliations
Review

A Historical Overview of Bacteriophage Therapy as an Alternative to Antibiotics for the Treatment of Bacterial Pathogens

Xavier Wittebole et al. Virulence.

Abstract

The seemingly inexorable spread of antibiotic resistance genes among microbial pathogens now threatens the long-term viability of our current antimicrobial therapy to treat severe bacterial infections such as sepsis. Antibiotic resistance is reaching a crisis situation in some bacterial pathogens where few therapeutic alternatives remain and pan-resistant strains are becoming more prevalent. Non-antibiotic therapies to treat bacterial infections are now under serious consideration and one possible option is the therapeutic use of specific phage particles that target bacterial pathogens. Bacteriophage therapy has essentially been re-discovered by modern medicine after widespread use of phage therapy in the pre-antibiotic era lost favor, at least in Western countries, after the introduction of antibiotics. We review the current therapeutic rationale and clinical experience with phage therapy as a treatment for invasive bacterial infection as novel alternative to antimicrobial chemotherapy.

Keywords: bacteriophage therapy; multidrug resistant pathogens; phage therapy; sepsis; septic shock.

Similar articles

See all similar articles

Cited by 74 PubMed Central articles

See all "Cited by" articles

References

    1. Sulakvelidze A. Bacteriophage: A new journal for the most ubiquitous organisms on Earth. Bacteriophage. 2011;1:1–2. doi: 10.4161/bact.1.1.15030. - DOI - PMC - PubMed
    1. Weinbauer MG. Ecology of prokaryotic viruses. FEMS Microbiol Rev. 2004;28:127–81. doi: 10.1016/j.femsre.2003.08.001. - DOI - PubMed
    1. Hanlon GW. Bacteriophages: an appraisal of their role in the treatment of bacterial infections. Int J Antimicrob Agents. 2007;30:118–28. doi: 10.1016/j.ijantimicag.2007.04.006. - DOI - PubMed
    1. d’Herelle F. Bacteriophage as a treatment in acute medical and surgical infections. Bull N Y Acad Med. 1931;7:329–48. - PMC - PubMed
    1. Abedon ST, Kuhl SJ, Blasdel BG, Kutter EM. Phage treatment of human infections. Bacteriophage. 2011;1:66–85. doi: 10.4161/bact.1.2.15845. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources

Feedback