Brain-derived neurotrophic factor loop 4 dipeptide mimetic GSB-106 activates TrkB, Erk, and Akt and promotes neuronal survival in vitro

Dokl Biochem Biophys. 2013 Jul-Aug:451:212-4. doi: 10.1134/S1607672913040121. Epub 2013 Aug 23.

Authors

T A Gudasheva¹, I O Logvinov, T A Antipova, S B Seredenin

Affiliation

¹ Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia.

PMID: 23975404
DOI: 10.1134/S1607672913040121

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomimetic Materials / administration & dosage
Brain-Derived Neurotrophic Factor / administration & dosage*
Cell Line
Cell Survival / drug effects
Dipeptides / administration & dosage*
Dose-Response Relationship, Drug
Extracellular Signal-Regulated MAP Kinases / metabolism*
Neurons / cytology
Neurons / drug effects*
Neurons / physiology*
Neuroprotective Agents / administration & dosage
Oxidative Stress / drug effects
Oxidative Stress / physiology
Proto-Oncogene Proteins c-akt / metabolism*
Rats
Receptor, trkB / metabolism*
Signal Transduction / drug effects
Signal Transduction / physiology
Up-Regulation / drug effects
Up-Regulation / physiology

Substances

Brain-Derived Neurotrophic Factor
Dipeptides
Neuroprotective Agents
Receptor, trkB
Proto-Oncogene Proteins c-akt
Extracellular Signal-Regulated MAP Kinases