Rapid-acquisition myocardial perfusion scintigraphy (MPS) on a novel gamma camera using multipinhole collimation and miniaturized cadmium-zinc-telluride (CZT) detectors: prognostic value and diagnostic accuracy in a 'real-world' nuclear cardiology service

Eur Heart J Cardiovasc Imaging. 2014 Mar;15(3):275-83. doi: 10.1093/ehjci/jet149. Epub 2013 Aug 23.


Aims: To study the prognostic value of rapid-acquisition adenosine stress-rest myocardial perfusion scintigraphy (MPS) on a gamma camera using multipinhole collimation and cadmium-zinc-telluride (CZT) detectors. The secondary aim was to assess the diagnostic accuracy of the technique compared with invasive coronary angiography.

Methods and results: Retrospective analysis of 1109 consecutive patients undergoing MPS in a routine clinical setting on a high-efficiency multipinhole gamma camera. MPS acquisition, performed with a standard injection of 550 MBq of (99m)Tc-tetrofosmin, required a mean (±SD) scanning time of 322 ± 51 s. The hard cardiac event rate at a median (inter-quartile range) follow-up of 624 (552-699) days was 0.4% (95% CI 0.1-1.1) in patients with no significant perfusion abnormality versus 6.8% (95% CI 4.3-10.7%, P < 0.001) in those with an abnormal scan. In a sub-group of 165 patients, comparison with obstructive coronary artery disease on X-ray angiography gave a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for rapid-acquisition MPS of 84% (95% CI 74-91), 79% (95% CI 68-87), 82% (95% CI 72-89), 81% (95% CI 70-89), and 82% (95% CI 73-89), respectively.

Conclusions: MPS performed on a CZT solid-state detector camera with multipinhole collimation is an evolutionary development that provides reliable prognostic and diagnostic information, while significantly reducing image acquisition time.

Keywords: cadmium–zinc–telluride; coronary artery disease; high efficiency; multipinhole collimation; myocardial perfusion scintigraphy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cadmium*
  • Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / instrumentation
  • Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / methods*
  • Cardiology / methods
  • Cohort Studies
  • Coronary Angiography / methods
  • Coronary Artery Disease / diagnostic imaging*
  • Female
  • Gamma Cameras*
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Myocardial Perfusion Imaging / instrumentation*
  • Myocardial Perfusion Imaging / methods
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Tellurium*
  • Young Adult
  • Zinc*


  • CdZnTe
  • Cadmium
  • Zinc
  • Tellurium