In celebration of the 100th anniversary of the lipid hypothesis of atherosclerosis

J Lipid Res. 2013 Nov;54(11):2946-9. doi: 10.1194/jlr.R043414. Epub 2013 Aug 23.


This year marks the 100th anniversary of the publication of Anitschkow's classic paper proposing the central role of hypercholesterolemia in atherogenesis. We at the Journal of Lipid Research take this occasion to acknowledge the debt we all owe to Anitschkow and his colleagues for getting us on the right track. As discussed below in detail, his contributions were insightful and went well beyond simply pinpointing hypercholesterolemia as a major etiologic factor. Anitschkow's work led him to define most of the key elements in the initiation and evolution of lesions in animal models of atherogenesis.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / blood*
  • Atherosclerosis / history*
  • Atherosclerosis / metabolism
  • Atherosclerosis / pathology
  • Cholesterol / blood*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Models, Biological*


  • Cholesterol