Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis

Clin Exp Immunol. 1990 Sep;81(3):368-72. doi: 10.1111/j.1365-2249.1990.tb05340.x.


We studied the sera of patients with progressive systemic sclerosis (PSS) for elevated levels of soluble interleukin-2 receptor (sIL-2R), interleukin-2 (IL-2) and interleukin-4 (IL-4). We also measured IL-2, IL-4 and B cell growth factor (BCGF) activity in supernatants of peripheral blood mononuclear cells from the same patients. The finding of elevated serum sIL-2R and IL-2, and the increased levels of IL-2, IL-4 and BCGF activity in culture supernatants indicates that T lymphocyte hyperactivity likely play a major role in PSS. The failure to detect under our experimental conditions a direct proliferative effect of recombinant IL-2 on enriched normal B cells might suggest that IL-4 is the cytokine mainly responsible of the BCGF activity recovered in PSS supernatants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • B-Lymphocytes / cytology
  • Cell Division
  • Cells, Cultured
  • Female
  • Humans
  • Interleukin-2 / metabolism*
  • Interleukin-4 / metabolism*
  • Leukocytes, Mononuclear / metabolism
  • Leukocytes, Mononuclear / pathology
  • Middle Aged
  • Receptors, Interleukin-2 / metabolism*
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / immunology*
  • Solubility
  • T-Lymphocytes / physiology


  • Interleukin-2
  • Receptors, Interleukin-2
  • Interleukin-4