[D-lactic acidosis and encephalopathy in short-bowel syndrome occurring during antibiotic treatment]

Gastroenterol Clin Biol. 1990;14(6-7):596-8.
[Article in French]


A 24 year-old patient with a short-bowel syndrome receiving home parenteral nutrition in addition to oral feeding for 32 months was treated by oral trimethoprim-sulfamethoxazole for urinary tract infection. Three days later, he developed neurologic disorders associated with severe hyperchloremic acidosis and high plasma level of D-lactate. This is a rare complication of intestinal malabsorption due to small bowel by-pass or extensive resection due to transient alteration of intestinal microflora induced by the oral antibiotic treatment. Diagnosis requires a high indice of suspicion.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acidosis, Lactic / blood
  • Acidosis, Lactic / complications*
  • Adult
  • Humans
  • Intestine, Small
  • Lactates / blood
  • Malabsorption Syndromes / complications*
  • Male
  • Nervous System Diseases / etiology
  • Syndrome
  • Trimethoprim, Sulfamethoxazole Drug Combination / adverse effects*
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Urinary Tract Infections / drug therapy


  • Lactates
  • Trimethoprim, Sulfamethoxazole Drug Combination