Mechanisms of apoptotic phosphatidylserine exposure

Cell Res. 2013 Nov;23(11):1247-8. doi: 10.1038/cr.2013.115. Epub 2013 Aug 27.


It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Cell Membrane / metabolism*
  • Humans
  • Phospholipid Transfer Proteins / metabolism*
  • Phospholipids / metabolism*


  • Phospholipid Transfer Proteins
  • Phospholipids
  • Calcium