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Case Reports
. 2014 Mar 1;55(2):205-9.
doi: 10.1093/jrr/rrt102. Epub 2013 Aug 26.

Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells

Mei Guo  1 , Zheng Dong, Jianhui Qiao, Changlin Yu, Qiyun Sun, Kaixun Hu, Guangxian Liu, Li Wei, Bo Yao, Qiuhong Man, Xuedong Sun, Zhiqing Liu, Zhiwu Song, Chengze Yu, Ying Chen, Qingliang Luo, Sugang Liu, Hui-Sheng Ai
Affiliations
Case Reports

Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells

Mei Guo et al. J Radiat Res. .

Abstract

This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy γ-radiation in a lethal (60)Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.

Keywords: HLA-mismatched stem cell transplantation; acute radiation syndrome; mesenchymal stem cell.

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Figures

Fig. 1.
Fig. 1.
Radiation damage in the patient after exposure. (A) head hair lost; (B) and (C) hands showing erythema and ulceration (days 24 and 44 after exposure, respectively); (D) extensive necrosis of the colon at the surgery.
Fig. 2.
Fig. 2.
Changes in the WBC and platelet count after exposure.
See this image and copyright information in PMC

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