Eyelash growth induced by topical prostaglandin analogues, bimatoprost, tafluprost, travoprost, and latanoprost in rabbits

J Ocul Pharmacol Ther. 2013 Nov;29(9):817-20. doi: 10.1089/jop.2013.0075. Epub 2013 Aug 27.


Purpose: Prostaglandin analogues (PGA) are ocular hypotensive agents used for the treatment of glaucoma. Hypertrichosis of the eyelashes has been reported in humans as a side effect. Eyelash growth was investigated with clinical trials in people using bimatoprost. Scattered reports of eyelash growth during the treatment of glaucoma with other PGA are also found in the literature. We investigated the effect of 4 different topical PGA on eyelash length.

Methods: Forty New Zealand white rabbits were divided into 4 groups and received daily topical application of bimatoprost, tafluprost, travoprost, and latanoprost in the left eye for 4 weeks. The right eye received no treatment. Eyelash length was measured in both eyes before and after treatment using a stainless steel digital caliper.

Results: Bimatoprost and tafluprost groups had significant increases in eyelash length. We did not observe significant eyelash growth in rabbits receiving travoprost and latanoprost after 1 month of treatment.

Conclusions: Today, only bimatoprost is approved for growing eyelashes, and our research shows that tafluprost could be further explored by the cosmetic and pharmaceutical industry. Additional research using travoprost and latanoprost as agents for eyelash growth should be performed in the future using prolonged treatment periods to determine whether or not these PGA induce eyelash growth, and investigate other possible side effects.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Amides / administration & dosage
  • Amides / pharmacology
  • Animals
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / pharmacology*
  • Bimatoprost
  • Cloprostenol / administration & dosage
  • Cloprostenol / analogs & derivatives
  • Cloprostenol / pharmacology
  • Eyelashes / drug effects*
  • Eyelashes / growth & development
  • Female
  • Hypertrichosis / chemically induced*
  • Latanoprost
  • Male
  • Prostaglandins F / administration & dosage
  • Prostaglandins F / pharmacology
  • Prostaglandins F, Synthetic / administration & dosage
  • Prostaglandins F, Synthetic / pharmacology
  • Rabbits
  • Travoprost


  • Amides
  • Antihypertensive Agents
  • Prostaglandins F
  • Prostaglandins F, Synthetic
  • tafluprost
  • Cloprostenol
  • Latanoprost
  • Bimatoprost
  • Travoprost