Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease

Cardiovasc Diabetol. 2013 Aug 28:12:124. doi: 10.1186/1475-2840-12-124.

Abstract

Background: Expression and activity of the fibroblast growth factor (FGF) 21 hormone-like protein are associated with development of several metabolic disorders. This study was designed to investigate whether serum FGF21 level was also associated with the metabolic syndrome-related cardiovascular disease, atherosclerosis, and its clinical features in a Chinese cohort.

Methods: Two-hundred-and-fifty-three subjects visiting the Cardiology Department (Sixth People's Hospital affiliated to Shanghai JiaoTong University) were examined by coronary arteriography (to diagnose coronary artery disease (CAD)) and hepatic ultrasonography (to diagnose non-alcoholic fatty liver disease (NAFLD)). Serum FGF21 level was measured by enzyme-linked immunosorbent assay and analyzed for correlation to subject and clinical characteristics. The independent factors of CAD were determined by multivariate logistic regression analysis.

Results: Subjects with NAFLD showed significantly higher serum FGF21 than those without NAFLD (388.0 pg/mL (253.0-655.4) vs. 273.3 pg/mL (164.9-383.7), P < 0.01). Subjects with CAD showed significantly higher serum FGF21, regardless of NAFLD diagnosis (P < 0.05). Serum FGF21 level significantly elevated with the increasing number of metabolic disorders (P for trend < 0.01). After adjustment of age, sex, and BMI, FGF21 was positively correlated with total cholesterol (P < 0.05) and triglyceride (P < 0.01). FGF21 was identified as an independent factor of CAD (odds ratio = 2.984, 95% confidence interval: 1.014-8.786, P < 0.05).

Conclusions: Increased level of serum FGF21 is associated with NAFLD, metabolic disorders and CAD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian People
  • Biomarkers / blood
  • Chi-Square Distribution
  • China / epidemiology
  • Coronary Angiography
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / ethnology
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Fatty Liver / blood
  • Fatty Liver / diagnostic imaging
  • Fatty Liver / ethnology
  • Female
  • Fibroblast Growth Factors / blood*
  • Humans
  • Logistic Models
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / ethnology
  • Middle Aged
  • Multivariate Analysis
  • Non-alcoholic Fatty Liver Disease
  • Odds Ratio
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Ultrasonography

Substances

  • Biomarkers
  • fibroblast growth factor 21
  • Fibroblast Growth Factors