Hepatitis B virus-induced hepatocellular carcinoma

Cancer Lett. 2014 Apr 10;345(2):216-22. doi: 10.1016/j.canlet.2013.08.035. Epub 2013 Aug 25.


Many factors are considered to contribute to hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signal pathways that associated with cell proliferation and apoptosis, and the impact of HBx C-terminal truncation in the development of HCC has been implicated. Recent studies by advanced sequencing technologies have revealed recurrent HBV DNA integration sites in hepatoma cells and susceptible genes/SNPs play an important role in the pathogenesis of liver cancer. Epigenetic changes, immune and inflammatory factors are also important contributing factors for liver cancer. This mini-review provides an overview on the recent development of HBV induced HCC.

Keywords: Carcinogenesis; HBV; HBVx; HCC.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / immunology
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / virology*
  • Cell Transformation, Viral*
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Regulation, Viral
  • Genotype
  • Hepatitis B / complications*
  • Hepatitis B / genetics
  • Hepatitis B / immunology
  • Hepatitis B / metabolism
  • Hepatitis B virus / genetics
  • Hepatitis B virus / immunology
  • Hepatitis B virus / metabolism
  • Hepatitis B virus / pathogenicity*
  • Humans
  • Inflammation Mediators / metabolism
  • Liver Neoplasms / genetics
  • Liver Neoplasms / immunology
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / virology*
  • Prognosis
  • Risk Factors
  • Signal Transduction
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Viral Regulatory and Accessory Proteins


  • Inflammation Mediators
  • Trans-Activators
  • Viral Regulatory and Accessory Proteins
  • hepatitis B virus X protein